Edorium Journal of

Nanotechnology

 
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Original Article
 
Micro and nanofluidic platforms for advanced diagnostics
Elena Angeli1, Valentina Mussi2, Paola Fanzio1, Chiara Manneschi3, Luca Repetto1, Giuseppe Firpo1, Patrizia Guida1, Vincenzo Ierardi1, Andrea Volpe4, Ugo Valbusa1
1PhD, Nanomed Labs, Physics Department, University of Genova, L.go Rosanna Benzi, 10, 16132, Genova, Italy.
2PhD, National Research Council, Institute for Complex Systems ISC-CNR, Via del Fosso del Cavaliere 100, 00133 Roma, Italy.
3PhD, National Research Council, Institute of Electronics, Computer and Telecommunication Engineering IEIIT-CNR, Via De Marini 6, 16149 Genoa, Italy.
4BSc, Nanomed Labs, Physics Department, University of Genova, L.go Rosanna Benzi, 10, 16132, Genova, Italy.

Article ID: 100001N02EA2014
doi:10.5348/N02-2014-1-OA-1

Address correspondence to:
Dr. Valentina Mussi
Via Fosso del Cavaliere
100, Rome
Italy. 00133
Phone: +390649934166
Fax: +390649934043
Email: valentina.mussi@isc.cnr.it

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How to cite this article
Angeli E, Mussi V, Fanzio P, Manneschi C, Repetto L, Firpo G, Guida P, Ierardi V, Volpe A, Valbusa U. Micro and nanofluidic platforms for advanced diagnostics. Edorium J Nanotechnol 2014;1:1–7.


Abstract
Aims: Sensitivity, selectivity and tunability are keywords to develop effective and reliable diagnostic and bioanalytical tools. In this context, micro and nanofluidic devices constitute a powerful and versatile answer to the growing and urgent demand for innovative solutions. Nevertheless, a precise control of size and functionality of such structures is necessary for ensuring advanced manipulation and sensing capabilities, up to single molecule level.
Methods: We report here on different strategies for the development of micro and nanofluidic platforms for advanced diagnostics based on the exploitation of the elastic properties of deformable materials, and on surface chemical functionalization processes.
Results: We demonstrated that applying a macroscopic mechanical compression to elastomeric nanostructures it is possible to increase their confining power and vary the dynamics of DNA translocation process, while the use of the chemical functionalization allows to tune both the size and the functionality of the biosensor.
Conclusion: We believe that a smart integration of these two approaches would allow a significant step forward for the fabrication of next-generation lab-on-chip devices for biomedical diagnostic applications.

Keywords: Nanochannel, Nanopore, Nanofluidics, Nanofabrication, Biosensing, Polymeric lab-on-chip

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Author Contributions:
Elena Angeli – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Valentina Mussi – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Paola Fanzio – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Chiara Manneschi – Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Luca Repetto – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Giuseppe Firpo – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Patrizia Guida – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Vincenzo Ierardi – Conception and design, Acquisition of data, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Andrea Volpe – Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Ugo Valbusa – Conception and design, Analysis and interpretation of data, Critical revision of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors E.A., M.V., L.R., G.F., P.G., V.I. and U.V. declare a financial interest in the company (Nanomed Srl) attempting to commercialize the technology described in this manuscript.
Copyright
© Elena Angeli et al. 2014; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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